2024年研究業績

Takahashi H, Nishitani K, Kawarasaki S, Martin-Morales A, Nagai H, Kuwata H, Tokura M, Okaze H, Mohri S, Ara T, Ito T, Nomura W, Jheng HF, Kawada T, Inoue K, Goto T.
• Metabolome analysis reveals that cyclic adenosine diphosphate ribose contributes to the regulation of differentiation in mice adipocyte.
  FASEB J. 2024 38(1):e23391. doi: 10.1096/fj.202300850RR. PMID: 38145327

2023年研究業績

Kwon J, Aoki Y, Takahashi H, Nakata R, Kawarasaki S, Ni Z, Yu R, Inoue H, Inoue K, Kawada T, Goto T.
• Inflammation-induced nitric oxide suppresses PPARalpha expression and function via downregulation of Sp1 transcriptional activity in adipocytes.
  Biochim Biophys Acta Gene Regul Mech. 2023 1866(4):194987. doi: 10.1016/j.bbagrm.2023.194987. PMID: 37739218
Kwon J, Yeh YS, Kawarasaki S, Minamino H, Fujita Y, Okamatsu-Ogura Y, Takahashi H, Nomura W, Matsumura S, Yu R, Kimura K, Saito M, Inagaki N, Inoue K, Kawada T, Goto T.
• Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes.
  iScience. 2023 26(3):106161. doi: 10.1016/j.isci.2023.106161. PMID: 36895651
Kawarasaki S, Sawazaki H, Iijima H, Takahashi H, Nomura W, Inoue K, Kawada T, Goto T.
• Combined treatment with teneligliptin and canagliflozin additively suppresses high-fat diet-induced body weight gain in mice with modulation of lipid metabolism-related gene expression.
  Eur J Pharmacol. 2023 947:175682. doi: 10.1016/j.ejphar.2023.175682. PMID: 36965744
Jheng HF, Takase M, Kawarasaki S, Ni Z, Mohri S, Hayashi K, Izumi A, Sasaki K, Shinyama Y, Kwon J, Ng SP, Takahashi H, Nomura W, Yu R, Ochiai K, Inoue K, Kawada T, Goto T.
• 8-Prenyl daidzein and 8-prenyl genistein from germinated soybean modulate inflammatory response in activated macrophages.
  Biosci Biotechnol Biochem. 2023 87(8):747-757. doi: 10.1093/bbb/zbad041. PMID: 37024261
Yeh YS, Iwase M, Kawarasaki S, Kwon J, Rodriguez-Velez A, Zhang X, Jeong SJ, Goto T, Razani B.
• Subcutaneous Transplantation of White Adipose Tissue.
  Methods Mol Biol. 2023 2662:183-192. doi: 10.1007/978-1-0716-3167-6_16. PMID: 37076681
Katsuya S, Kawata Y, Goto T, Tsubota J.
• Daily Intake of D-β-Hydroxybutyric Acid (D-BHB) Reduces Body Fat in Japanese Adult Participants: A Randomized, Double-Blind, Placebo-Controlled Study.
  J Nutr Sci Vitaminol. 2023 69(2):121-128. doi: 10.3177/jnsv.69.121. PMID: 37121721
高橋春弥, 後藤剛
• 褐色脂肪細胞とベージュ脂肪細胞の多様な役割と制御機構.
  褐色脂肪細胞、ベージュ脂肪細胞の機能を制御する代謝経路.
  バイオインダストリー. 2023 40(5):37-44.

2022年研究業績

Takahashi H, Tokura M, Kawarasaki S, Nagai H, Iwase M, Nishitani K, Okaze H, Mohri S, Ito T, Ara T, Jheng HF, Nomura W, Kawada T, Inoue K, Goto T.
• Metabolomics reveals inosine 5'-monophosphate is increased during mice adipocyte browning.
  J Biol Chem. 2022 298(10):102456. doi: 10.1016/j.jbc.2022.102456. PMID: 36063990
Ng SP, Nomura W, Takahashi H, Inoue K, Kawada T, Goto T, Inoue Y.
• Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1-p38-mTORC1 signaling axis in adipocytes.
  Biochem J. 2022 479(21):2279-2296. doi: 10.1042/BCJ20220271. PMID: 36256829
Kawarasaki S, Matsuo K, Kuwata H, Zhou L, Kwon J, Ni Z, Takahashi H, Nomura W, Kenmotsu H, Inoue K, Kawada T, Goto T.
• Screening of flavor compounds using Ucp1-luciferase reporter beige adipocytes identified 5-methylquinoxaline as a novel UCP1-inducing compound.
  Biosci Biotechnol Biochem. 2022 86(3):380-389. doi: 10.1093/bbb/zbab216. PMID: 34935880
Mohri S, Takahashi H, Sakai M, Waki N, Takahashi S, Aizawa K, Suganuma H, Ara T, Sugawara T, Shibata D, Matsumura Y, Goto T, Kawada T.
• Integration of bioassay and non-target metabolite analysis of tomato reveals that β-carotene and lycopene activate the adiponectin signaling pathway, including AMPK phosphorylation.
  PLoS One. 2022 17(7):e0267248. doi: 10.1371/journal.pone.0267248. PMID: 35776737
Matsumura S, Miyakita M, Miyamori H, Kyo S, Ishikawa F, Sasaki T, Jinno T, Tanaka J, Fujita K, Yokokawa T, Goto T, Momma K, Takenaka S, Inoue K.
• CRTC1 deficiency, specifically in melanocortin-4 receptor-expressing cells, induces hyperphagia, obesity, and insulin resistance.
  FASEB J. 2022 36(12):e22645. doi: 10.1096/fj.202200617R. PMID: 36349991
Harada N, Kubo K, Onishi T, Kitakaze T, Goto T, Inui H, Yamaji R.
• Androgen receptor suppresses β-adrenoceptor-mediated CREB activation and thermogenesis in brown adipose tissue of male mice.
  J Biol Chem. 2022 298(12):102619. doi: 10.1016/j.jbc.2022.102619. PMID: 36272644
Matsumura S, Miyakita M, Miyamori H, Kyo S, Shima D, Yokokawa T, Ishikawa F, Sasaki T, Jinno T, Tanaka J, Goto T, Momma K, Ishihara K, Berdeaux R, Inoue K.
• Stimulation of Gs signaling in MC4R cells by DREADD increases energy expenditure, suppressing food intake, and increasing locomotor activity in mice.
  Am J Physiol Endocrinol Metab. 2022 322(5):E436-E445. doi: 10.1152/ajpendo.00439. PMID: 35344393
Tanaka J, Ishikawa F, Jinno T, Miyakita M, Miyamori H, Sasaki T, Yokokawa T, Goto T, Inoue K, Matsumura S.
• Disruption of CRTC1 and CRTC2 in Sim1 cells strongly increases high-fat diet intake in female mice but has a modest impact on male mice.
  PLoS One. 2022 17(1):e0262577. doi: 10.1371/journal.pone.0262577. PMID: 35020776
Kaneko K, Takekuma Y, Goto T, Ohinata K.
• An orally active plant Rubisco-derived peptide increases neuronal leptin responsiveness.
  Sci Rep. 2022 12(1):8599. doi: 10.1038/s41598-022-12595-6. PMID: 35597815
Nomura W, Ng SP, Takahara T, Maeda T, Kawada T, Goto T, Inoue Y.
• Roles of phosphatidylserine and phospholipase C in the activation of TOR complex 2 signaling in Saccharomyces cerevisiae.
  J Cell Sci. 2022 135(17):jcs259988. doi: 10.1242/jcs.259988. PMID: 35912799
Kenmochi M, Kawarasaki S, Takizawa S, Okamura K, Goto T, Uchida K.
• Involvement of mechano-sensitive Piezo1 channel in the differentiation of brown adipocytes.
  J Physiol Sci. 2022 72(1):13. doi: 10.1186/s12576-022-00837-1. PMID: 35725398
後藤剛, 川原崎聡子, Kwon Jungin, 高橋春弥, 井上和生, 河田照雄
• 栄養・代謝物シグナルと食品機能 転写、エピゲノムの制御から代謝性疾患の治療・予防に向けて.
  食餌脂肪酸・脂肪酸代謝物シグナルによるエネルギー代謝制御 　- 褐色脂肪組織機能を中心に - .
  実験医学増刊. 2022 40(7):1005-1013.

2021年研究業績

Nakamizo S, Dutertre CA, Khalilnezhad A, Zhang XM, Lim S, Lum J, Koh G, Foong C, Yong PJA, Tan KJ, Sato R, Tomari K, Yvan-Charvet L, He H, Guttman-Yassky E, Malleret B, Shibuya R, Iwata M, Janela B, Goto T, Lucinda TS, Tang MBY, Theng C, Julia V, Hacini-Rachinel F, Kabashima K, Ginhoux F.
• Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis.
  J Exp Med. 2021 218(9):e20202345. doi: 10.1084/jem.20202345.
Ng SP, Nomura W, Takahashi H, Inoue K, Kawada T, Goto T.
• Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytes.
  Biochem Biophys Rep. 2021 28:101127. doi: 10.1016/j.bbrep.2021.101127.
Matsumura S, Ishikawa F, Sasaki T, Terkelsen MK, Ravnskjaer K, Jinno T, Tanaka J, Goto T, Inoue K.
• Loss of CREB Coactivator CRTC1 in SF1 Cells Leads to Hyperphagia and Obesity by High-fat Diet But Not Normal Chow Diet.
  Endocrinology. 2021 162(9):bqab076. doi: 10.1210/endocr/bqab076.
Tanaka H, Matsumoto H, Takahashi H, Hosonuma M, Sato S, Ogura K, Oishi Y, Masaki R, Sakai K, Sekimoto T, Kondo S, Tsujita H, Tsukamoto S, Sumida A, Okada N, Inoue K, Shinke T.
• Linear concentration-response relationship of serum caffeine with adenosine-induced fractional flow reserve overestimation: a comparison with papaverine.
  EuroIntervention. 2021 17(11):e925-e931. doi: 10.4244/EIJ-D-21-00453.
Takahashi H, Ochiai K, Sasaki K, Izumi A, Shinyama Y, Mohri S, Nomura W, Jheng HF, Kawada T, Inoue K, Goto T.
• Metabolome analysis revealed that soybean-Aspergillus oryzae interaction induced dynamic metabolic and daidzein prenylation changes.
  PLoS One. 2021 16(7):e0254190. doi: 10.1371/journal.pone.0254190.
Bonora E, Chakrabarty S, Kellaris G, Tsutsumi M, Bianco F, Bergamini C, Ullah F, Isidori F, Liparulo I, Diquigiovanni C, Masin L, Rizzardi N, Cratere MG, Boschetti E, Papa V, Maresca A, Cenacchi G, Casadio R, Martelli P, Matera I, Ceccherini I, Fato R, Raiola G, Arrigo S, Signa S, Sementa AR, Severino M, Striano P, Fiorillo C, Goto T, Uchino S, Oyazato Y, Nakamura H, Mishra SK, Yeh YS, Kato T, Nozu K, Tanboon J, Morioka I, Nishino I, Toda T, Goto YI, Ohtake A, Kosaki K, Yamaguchi Y, Nonaka I, Iijima K, Mimaki M, Kurahashi H, Raams A, MacInnes A, Alders M, Engelen M, Linthorst G, de Koning T, den Dunnen W, Dijkstra G, van Spaendonck K, van Gent DC, Aronica EM, Picco P, Carelli V, Seri M, Katsanis N, Duijkers FAM, Taniguchi-Ikeda M, De Giorgio R.
• Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy.
  Brain. 2021 144(5):1451-1466. doi: 10.1093/brain/awab056.
Mutsnaini L, Yang J, Kim J, Kim CS, Lee CH, Kim MS, Park T, Goto T, Yu R.
• Filbertone protects obesity-induced hypothalamic inflammation by reduction of microglia-mediated inflammatory responses.
  Biotechnol Bioprocess Eng. 2021 26(1):86-92. doi: 10.1007/s12257-020-0220-5.

2020年研究業績

Kawarasaki S, Sawazaki H, Iijima H, Ng SP, Kwon J, Mohri S, Iwase M, Jheng HF, Takahashi H, Nomura W, Inoue K, Kawada T, Goto T.
• Comparative Analysis of the Preventive Effects of Canagliflozin, a Sodium-Glucose Co-Transporter-2 Inhibitor, on Body Weight Gain Between Oral Gavage and Dietary Administration by Focusing on Fatty Acid Metabolism.
  Diabetes Metab Syndr Obes. 2020 Nov 16;13:4353-4359. doi: 10.2147/DMSO.S269916.
Takata K, Goto T, Kuroda M, Kimura Y, Harada I, Ueda K, Kawada T, Kioka N.
• Stiffness of the extracellular matrix regulates differentiation into beige adipocytes.
  Biochem Biophys Res Commun. 2020 Aug 25:S0006-291X(20)31586-2. doi: 10.1016/j.bbrc.2020.08.032.
Tada A, Misawa E, Tanaka M, Saito M, Nabeshima K, Yamauchi K, Abe F, Goto T, Kawada T.
• Investigating Anti-Obesity Effects by Oral Administration of Aloe vera Gel Extract (AVGE): Possible Involvement in Activation of Brown Adipose Tissue (BAT).
  J Nutr Sci Vitaminol (Tokyo). 2020;66(2):176-184. doi: 10.3177/jnsv.66.176.
Iwase M, Tokiwa S, Seno S, Mukai T, Yeh YS, Takahashi H, Nomura W, Jheng HF, Matsumura S, Kusudo T, Osato N, Matsuda H, Inoue K, Kawada T, Goto T.
• Glycerol kinase stimulates uncoupling protein 1 expression by regulating fatty acid metabolism in beige adipocytes.
  J Biol Chem. 2020 May 15;295(20):7033-7045. doi: 10.1074/jbc.RA119.011658.
Jheng HF, Hayashi K, Matsumura Y, Kawada T, Seno S, Matsuda H, Inoue K, Nomura W, Takahashi H, Goto T.
• Anti-Inflammatory and Antioxidative Properties of Isoflavones Provide Renal Protective Effects Distinct from Those of Dietary Soy Proteins against Diabetic Nephropathy.
  Mol Nutr Food Res. 2020 May;64(10):e2000015. doi: 10.1002/mnfr.202000015.
Iwase M, Sakai S, Seno S, Yeh YS, Kuo T, Takahashi H, Nomura W, Jheng HF, Horton P, Osato N, Matsuda H, Inoue K, Kawada T, Goto T.
• Long non-coding RNA 2310069B03Rik functions as a suppressor of Ucp1 expression under prolonged cold exposure in murine beige adipocytes.
  Biosci Biotechnol Biochem. 2020 Feb;84(2):305-313. doi: 10.1080/09168451.2019.1677451.
岩瀬麻里, 川原崎聡子, 毛利晋輔, 高橋春弥, 野村亘, Huei-Fen Jheng, 井上和生, 河田照雄, 後藤剛
• 脂肪組織機能を制御する食品由来成分に関する研究.
  機能性食品と薬理栄養 日本機能性食品医用学会誌. 2020 13(5):252-257

2019年研究業績

Hara H, Takahashi H, Mohri S, Murakami H, Kawarasaki S, Iwase M, Sugiura M, Takahashi N, Goto T, Kawada T.
• β-cryptoxanthin induces UCP-1 expression via RAR pathway in adipose tissue.
  J Agric Food Chem. 2019 Sep 25;67(38):10595-10603. doi: 10.1021/acs.jafc.9b01930.
Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White PJ, McGarrah RW, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S.
• BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.
  Nature. 2019 Aug;572(7771):614-619. doi: 10.1038/s41586-019-1503-x.
Suzuki M, Chen HJ, Tomonaga S, Hashimoto O, Kawada T, Matsui T, Funaba M.
• Chronic retinoic acid treatment induces differentiation and changes in the metabolite levels of brown (pre)adipocytes.
  Cell Biochemistry and Function. 2019 Jul;37(5):377-384. doi: 10.1002/cbf.3416.
Kawarasaki S, Kuwata H, Sawazaki H, Sakamoto T, Nitta T, Kim CS, Jheng HF, Takahashi H, Nomura W, Ara T, Takahashi N, Tomita K, Yu R, Kawada T, Goto T.
• A new mouse model for noninvasive fluorescence-based monitoring of mitochondrial UCP1 expression.
  FEBS letters. 2019 Jun;593(11):1201-1212. doi: 10.1002/1873-3468.13430.
Ng SP, Nomura W, Mohri S, Takahashi H, Jheng HF, Ara T, Nagai H, Ito T, Kawada T, Goto T.
• Soy hydrolysate enhances the isoproterenol-stimulated lipolytic pathway through an increase in β-adrenergic receptor expression in adipocytes.
  Biosci Biotechnol Biochem. 2019 Sep;83(9):1782-1789. doi: 10.1080/09168451.2019.1611413.
Kiriyama K, Goto T, Yamamoto H, Ara T, Takahashi H, Jheng HF, Nomura W, Inoue H, Nakata R, Kawada T.
• Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice.
  Journal of Functional Foods. 2019; 54: 529-535.
Yuliana A, Daijo A, Jheng HF, Kwon J, Nomura W, Takahashi H, Ara T, KawadaT, Goto T.
• Endoplasmic Reticulum Stress Impaired Uncoupling Protein 1 Expression via the Suppression of Peroxisome Proliferator-Activated Receptor γ Binding Activity in Mice Beige Adipocytes.
  Int J Mol Sci. 2019 Jan 11;20(2). pii: E274. doi: 10.3390/ijms20020274.
後藤剛・金�a智・川原崎聡子・高橋春弥・河田照雄．
• 食餌由来腸内細菌代謝産物による褐色脂肪組織機能調節．
  オレオサイエンス第19巻第4号 (2019年)

2018年研究業績

Aoki Y, Sugawara T, Yanagihara S, Takahashi H, Nomura W, Jheng HF, Ara T, Goto T, Kawada T, Sawada D.
• 10-Hydroxyoctadecanoic acid from Lactobacillus amylovorus CP1563 activates PPARα and improves dyslipidemia.
  Pharmacometrics. 2018; 95: 73-82.
Shibata M, Hirotsuka M, Mizutani Y, Takahashi H, Kawada T, Matsumiya K, Hayashi Y, Matsumura Y.
• Thermal Treatment of Soybean Seeds can Improve the Quality of Soymilk by Enhancing the Extraction Efficiency of "Kokumi" Taste Components.
  Food Science And Technology Research. 2018; 24(6) 1111-1119.
Takahashi S, Waki N, Mohri S, Takahashi H, Ara T, Aizawa K, Suganuma H, Kawada T, Goto T.
• Apo-12'-lycopenal, a Lycopene Metabolite, Promotes Adipocyte Differentiation via Peroxisome Proliferator-activated Receptor Gamma Activation.
  J Agric Food Chem. 2018 Dec 19;66(50):13152-13161. doi: 10.1021/acs.jafc.8b04736.
Yeh YS, Jheng HF, Iwase M, Kim M, Mohri S, Kwon J, Kawarasaki S, Li Y, Takahashi H, Ara T, Nomura W, Kawada T, Goto T.
• The Mevalonate Pathway Is Indispensable for Adipocyte Survival.
  iScience. 2018 Oct 21;9:175-191. doi: 10.1016/j.isci.2018.10.019. [Epub ahead of print]
Takeda K, Sawazaki H, Takahashi H, Yeh YS, Jheng HF, Nomura W, Ara T, Takahashi N, Seno S, Osato N, Matsuda H, Kawada T, Goto T.
• The dipeptidyl peptidase-4 (DPP-4) inhibitor teneligliptin enhances brown adipose tissue function, thereby preventing obesity in mice.
  FEBS Open Bio. 2018 Sep 19;8(11):1782-1793. doi: 10.1002/2211-5463.12498. eCollection 2018 Nov.
Suzuki M, Murakami M, Shirai M, Hashimoto O, Kawada T, Matsui T, Funaba M.
• Role of estradiol and testosterone in Ucp1 expression in brown/beige adipocytes.
  Cell Biochem Funct. 2018 Nov 8. doi: 10.1002/cbf.3366. [Epub ahead of print]
Yuliana A, Jheng HF, Kawarasaki S, Nomura W, Takahashi H, Ara T, Kawada T, Goto T.
• β-adrenergic Receptor Stimulation Revealed a Novel Regulatory Pathway via Suppressing Histone Deacetylase 3 to Induce Uncoupling Protein 1 Expression in Mice Beige Adipocyte.
  Int J Mol Sci. 2018 Aug 17;19(8). pii: E2436. doi: 10.3390/ijms19082436.
Kim J, Kwon YH, Kim CS, Tu TH, Kim BS, Joe Y, Chung HT, Goto T, Kawada T, Park T, Choi MS, Kim MS, Yu R.
• The involvement of 4-1BB/4-1BBL signaling in glial cell-mediated hypothalamic inflammation in obesity.
  FEBS Open Bio. 2018 Apr 19;8(5):843-853. doi: 10.1002/2211-5463.12426.
Kawada T.
• Food-derived regulatory factors against obesity and metabolic syndrome.
  Biosci Biotechnol Biochem. 2018 Apr; 82(4): 547-553.
Zheng J, Li Z, Manabe Y, Kim M, Goto T, Kawada T, Sugawara T.
• Siphonaxanthin, a Carotenoid From Green Algae, Inhibits Lipogenesis in Hepatocytes via the Suppression of Liver X Receptor α Activity.
  Lipids.Jan; 53(1): 41-52.
An JY, Jheng HF, Nagai H, Sanada K, Takahashi H, Iwase M, Watanabe N, Kim YI, Teraminami A, Takahashi N, Nakata R, Inoue H, Seno S, Matsuda H, Kawada T, Goto T
• A phytol-enriched diet activates PPARα in the liver and brown adipose tissue to ameliorate obesity-induced metabolic abnormalities.
  Mol Nutr Food Res. 2018 Mar; 62(6): e1700688.
Shibata M, Hirotsuka M, Mizutani Y, Takahashi H, Kawada T, Matsumiya K, Hayashi Y, Matsumura Y.
• Diversity of γ-glutamyl peptides and oligosaccharides, the "kokumi" taste enhancers, in seeds from soybean mini core collections.
  Biosci Biotechnol Biochem. 2018 Mar; 82(3): 507-514.
Kida R, Noguchi T, Murakami M, Hashimoto O, Kawada T, Matsui T, Funaba M.
• Supra-pharmacological concentration of capsaicin stimulates brown adipogenesis through induction of endoplasmic reticulum stress.
  Sci Rep. 2018 Jan 16;8(1):845. doi: 10.1038/s41598-018-19223-2.
Mohri S, Takahashi H, Sakai M, Takahashi S, Waki N, Aizawa K, Sugamura H, Ara T. Matsumura Y, Shibata D, Goto T, Kawada T.
• Wide-range screening of anti-inflammatory compounds in tomato using LC-MS and elucidating the mechanism of their functions.
  PLOS ONE. 2018 Jan 12;13(1):e0191203
Ohue-Kitano R, Yasuoka Y, Goto T, Kitamura N, Park S-B, Kishino S, Kimura I, Kasubuchi M, Takahashi H, Li Y, Yeh Y-S, Jheng H-F, Iwase M, Tanaka M, Masuda S, Inoue T, Yamakage H, Kusakabe T, Tani T, Shimatsu A, Ogawa J, Satoh-Asahara N, Kawada T.
• Alpha-linolenic acid-derived metabolites from gut lactic acid bacteria induce differentiation of anti-inflammatory M2 macrophages through G protein-coupled receptor 40.
  FASEB J 2018 Jan;32(1):304-318. Dec10.1096/fj.201700273R.
高橋信之、河田照雄.
• マッキー生化学（第6版）第16章「代謝の統合的理解」翻訳.
  化学同人. 2018年.

2017年研究業績

Takahashi H, Sanada K, Nagai H, Li Y, Aoki Y, Ara T, Seno S, Matsuda H, Yu R, Kawada T, Goto T.
• Over-expression of PPARα in obese mice adipose tissue improves insulin sensitivity
  Biochem Biophys Res Commun.2017 Nov4; 493(1): 108-114
Shibata M, Hirotsuka M, Mizutani Y, Takahashi H, Kawada T, Matsumiya K, Hayashi Y, Matsumura Y.
• Isolation and characterization of key contributors to the "kokumi" taste in soybean seeds.
  Biosci Biotechnol Biochem. 2017 Nov; 81(11):2168-2177. doi:10.1080/09168451.2017.1372179.
Nakato J, Ho YY, Omae R, Mizushige T, Uchida K, Tominaga M, Kim M, Goto T, Takahashi N, Kawada T, Akiduki S, Kanamoto R, Ohinata K.
• L-Ornithine and L-lysine stimulate gastrointestinal motility via transient receptor potential vanilloid 1.
  Mol Nutr Food Res 2017 Nov; 61(11)
Kim M, Furuzono T, Yamakuni K, Li Y, KimY-I, Takahashi H, Ohue-Kitano R, Jheng H-F, Takahashi N, Kano Y, Yu R, Kishino S, Ogawa J, Uchida K, Yamazaki J, Tominaga M, Kawada T, Goto T.
• 10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, enhances energy metabolism by activation of TRPV1.
  FASEB J 2017 Nov; 31(11):5036-5048
Yang J, Kim CS, Tu TH, Kim MS, Goto T, Kawada T, Choi MS, Park T, Sung MK, Yun JW, Choe SY, Lee JH, Joe Y, Choi HS, Back SH, Chung HT, Yu R.
• Quercetin Protects Obesity-Induced Hypothalamic Inflammation by Reducing Microglia-Mediated Inflammatory Responses via HO-1 Induction.
  Nutrients 2017 Jun 23;9(7). pii: E650.
Iwase M, Yamamoto T, Nishimura K, Takahashi H, Mohri S, Li Y, Jheng HF, Nomura W, Takahashi N, Kim CS, Yu R, Taniguchi M, Baba K, Murakami S, Kawada T, Goto T.
• Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation
  Lipids 52: 657-664 (2017)
Kwon YH, Kim J, Kim CS, Tu TH, Kim MS, Suk K, Kim DH, Lee BJ, Choi HS, Park T, Choi MS, Goto T, Kawada T, Ha TY, Yu R.
• Hypothalamic lipid-laden astrocytes induce microglia migration and activation
  FEBS Letters 591:1742-1751 (2017)
Yang H-E, Li Y, Nishimura A, Jheng H-F, Yuliana A, Kitano-Ohue R, Nomura W, Takahashi N, Kim C-S, Yu R, Kitamura N, Park S-B, Kishino S, Ogawa J, Kawada T, Goto T.
• Synthesized enone fatty acids resembling metabolites from gut microbiota suppress macrophage-mediated inflammation in adipocytes
  Mol Nutr Food Res 2017 Oct; 61(10)
Goto T, Hirata M, Aoki Y, Iwase M, Takahashi H, Kim M, Li Y, Jheng H-F, Nomura W, Takahashi N, Kim C-S, Yu R, Seno S, Matsuda H , Aizawa-Abe M, Ebihara K, Itoh N, Kawada T.
• The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-α agonist-induced amelioration of metabolic disorders in obese mice
  J Biol Chem. 2017 Jun 2;292(22):9175-9190.
Yu R, Le N H, Kim C-S ,Tu T H, Kim B-S, Park T, ParK H Y, Goto T, Kawada T, Ha T-Y.
• Absence of 4-1BB reduces obesity-induced atrophic response in skeletal muscle
  J Inflamm (Lond). 2017 May 11;14:9. doi: 10.1186/s12950-017-0156-5.
Oguri Y, Fujita Y, Abudukadier A, Ohashi A, Goto T, Furuta F, Obara A, Fukushima T, Matsuo N, Kim M, Hosokawa M, Kawada T, Hasegawa H, Inagaki N.
• Tetrahydrobiopterin activates brown adipose tissue and regulates systemic energy metabolism
  JCI Insight. 2017 May 4;2(9). pii: 91981. doi: 10.1172/jci.insight.91981.
Jheng H-F, Hirotsuka M, Goto T, Shibata M, Matsumura Y, Kawada T.
• Dietary Low-Fat Soy Milk Powder Retards Diabetic Nephropathy Progression via Inhibition of Renal Fibrosis and Renal Inflammation
  Mol Nutr Food Res 2017 Mar,61(3) doi:10. 1002/mnfr.201600461.Equb 2016 Nov 29.

2016年研究業績

Takahashi H, Chi H-Y, Mohri S, Kamakari K, Nakata K, Ochijo N, Nakata R, Inoue H, Goto T, Kawada T.
• Rice Koji Extract Enhances Lipid Metabolism through Proliferator- Activated Receptor Alpha (PPARα) Activation in Mouse Liver
  J Agric Food Chem. 64: 8848-8856 (2016)
Oi-Kano Y, Iwasaki Y, Nakamura T, Watanabe T, Goto T, KawadaT, Watanabe K, Iwai K.
• Oleuropein aglycone enhances UCP1 expression in brown adipose tissue in high-fat-diet-induced obese rats by activating β-adrenergic signaling
  J Nutr Biochem 40: 209-218 (2016)
Asano H, Kida R, Muto K, Nara TY, Kato K, Hashimoto O, Kawada T, Matsui T, Funaba M.
• Modulation of brown adipocyte activity by milk by-products: Stimulation of brown adipogenesis by buttermilk.
  Cell Biochem Funct. 34: 647-656 (2016)
Goto T, Kim MJ, Takahashi H, Takahashi N, Kawada T.
• Food intake and thermogenesis in adipose tissue
  Korean J Obesity 25:109-114(2016)
Yeh Y-S, Takahashi N, Egawa K, Takahashi H, Jheng H-F, Kim Y-I, Kawada T, Goto T.
• Geranylgeranyl pyrophosphate performs as an endogenous regulator of adipocyte function via suppressing the LXR pathway
  Biochem Biophys Res Commun. 478:1317-1322(2016)
Li Y, Goto T, Ikutani R, Lin S, Takahashi N, Takahashi H, Jheng H-F, Taniguchi M, Baba K, Murakami S, Kawada T.
• Xanthoangelol and 4-hydroxyderrcin suppress obesity-induced inflammatory responses
  Obesity 24:2351-2360(2016)
Sun W, Uchida K, Takahashi N, Iwata Y, Wakabayashi S, Goto T, Kawada T, Tominaga M.
• Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes
  European J Physiol. 468:1527-1540(2016)
Kobayashi M, Suzuki M, Ohno T, Tsuzuki K, Taniguchi C, Takeishi S, Kawada T, Kim Y-I, Murai A, Horio F.
• Detection of differentially expressed candidate genes for a fatty liver QTL on mouse chromosome 12.
  BMC Genetics (2016) 17:73 DOI 10.1186/s12863-016-0385-2
Li Y, Goto T, Yamakuni K, Takahashi H, Takahashi N, Jheng J-F, Nomura W, Taniguchi M, Baba K, Murakami S, Kawada T.
• 4-Hydroxyderricin, as a PPARγ agonist, promotes adipogenesis, adiponectin secretion, and glucose uptake in 3T3-L1 cells
  Lipids 51:787-795(2016)
Yamamoto T, Li Y, Hanafusa Y, Yeh Y-S, Maruki-Uchida H, Kawakami S, Sai M, Goto T, Ito T, Kawada T.
• Piceatannol Exhibits Anti-inflammatory Effects on Macrophages Interacting with Adipocytes
  Food Science & Nutrition　5:76-85(2016)
Nakamura F, Ishida Y, Sawada D, Ashida N, Sugawara T, Sakai M, Goto T, Kawada T, Fujiwara S.
• Fragmented Lactic Acid Bacterial Cells Activate Peroxisome Proliferator-Activated Receptors and Ameliorate Dyslipidemia in Obese Mice.
  J Agric Food Chem. (2016) 64:2549-2559.
Sakamoto T, Nitta T, Maruno K, Yeh YS, Kuwata H, Tomita K, Goto T, Takahashi N, Kawada T.
• Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 expression in mice
  Am J Physiol. Endocrinology and Metabolism 310:E676-E687(2016)
Sun　W, Uchida K, Suzuki Y, Zhou Y, Kim M, Takayama Y, Takahashi N, Goto T, Wakabayashi S, Kawada T, Iwata Y, Tominaga M.
• Lack of TRPV2 impaired thermogenesis in mouse brown adipose tissue.
  EMBO Reports 17:383-399(2016)
Kida R, Yoshida H, Murakami M, Shirai M, Hashimoto O, Kawada T, Matsui T, Funaba M.
• Direct action of capsaicin in brown adipogenesis and activation of brown adipocytes.
  Cell Biochem Funct. (2016) 34:34-41.
Goto T, Naknukool S, Yoshitake R, Hanafusa Y, Tokiwa S, Li Y, Sakamoto T, Nitta T, Kim MJ, Takahashi N, Yu R, Daiyasu H, Seno S, Matsuda H, Kawada T.
• Proinflammatory cytokine interleukin-1beta suppresses cold-induced thermogenesis in adipocytes
  Cytokine. (2016) 77:107-114.
水野雄太、瀬尾茂人、渡邊誓旅、竹中要一、平松拓郎、後藤剛、河田照雄、松田秀雄
• Deep learningを用いた脂肪組織画像における細胞の認識
  情報処理学会研究報告 vol.2016-MPS-107 No.10: 1-6 (2016)　
河田　照雄
• 脂肪を味方にする科学〜食の機能性からの取組み〜
  食品加工技術：日本食品機会研究会誌　36:138-142(2016)　
河田　照雄
• 褐色脂肪と中年太り?食品から誘導される体熱産生のしくみ
  実験医学　34巻12月号（2016）
河田　照雄
• 特定保健用食品と新機能性食品制度
  生物工学　印刷中
後藤剛、高橋春弥、高橋信之、河田照雄
• PPARα特集「食品成分によるPPARαの活性化」
  The Lipids　印刷中
河田　照雄
• 「肥満・エネルギー代謝とポリフェノール」
  日本ポリフェノール学会誌　(2016)総説
後藤剛、河田照雄
• 生活習慣病と栄養 ：「生活習慣病と機能性食品 」
  CLINICAL CALCIUM 　2016年３月号

2015年研究業績

Goto T, Takahashi N, Kawada T.
• Food Components Modulate Obesity and Energy Metabolism via the Transcriptional Regulation of Lipid-Sensing Nuclear Receptors.
  J Nutr Sci Vitaminol (Tokyo). (2015) 61: S128-130.
Kim MJ, Goto T, Yu R, Uchida K, Tominaga M , Kano Y , Takahashi N, Kawada T.
• Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the 2 sympathetic nervous system
  Scientific Reports (2015) Dec 17; 5:18013.
Huei-Fen Jheng, Pei-Jane Tsai, Yi-Lun Chuang, Yi-Ting Shen, Ting-An Tai, Wen-Chung Chen, Chuan-Kai Chou, Li-Chun Ho, Ming-Jer Tang, Kuei-Tai A. Lai, Junne-Ming Sung, and Yau-Sheng Tsai.
• Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy
  Disease Models & Mechanisms, (2015) 8, 1311-1321.
Kim CS, Kwon Y, Choe SY, Hong SM, Yoo H, Goto T, Kawada T, Choi HS, Joe Y, Chung HT, Yu R.
• Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1
  Nutr Metab (Lond). 2015 Oct 6;12:33
Takahashi H, Kamakari K, Goto T, Hara H, Mohri S, Nakata R, Inoue H, Suzuki H, Shibata D, Takahashi N, Kawada T.
• 9-oxo-10(E),12(Z),15(Z)-octadecatrienoic acid activates peroxisome proliferator-activated receptor-α in hepatocytes
  Lipids. (2015) 50:1083-1091.
Nanthirudjanar T, Furumoto H, Zheng J, Kim YI, Goto T, Takahashi N, Kawada T, Park SB, Hirata A, Kitamura N, Kishino S, Ogawa J, Hirata T, Sugawara T.
• Gut Microbial Fatty Acid Metabolites Reduce Triacylglycerol Levels in Hepatocytes
  Lipids. (2015) 50:1093-1102.
Taketani K, Hoshino S, Uemura T, Goto T, Takahashi N, Tsuge N, Kawada T.
• An efficient purification method for quantitative determinations of protodioscin, dioscin and diosgenin in plasma of fenugreek-fed mice.
  J. Nutr. Sci. Vitaminol. 2015;61(6):465-70.
Matsumoto H, Ushimaru S, Matsuda T, Shimada T, Mikuri M, Takahashi H, Takahashi N, Kawada T, Yamazaki T.
• Is Caffeine Abstention Necessary before Adenosine-Induced Fractional Flow Reserve Measurement?
  J. Amer. Coll. of Cardiol. (2015) 66:1943-1945.
Goto T, Kim YI, Furuzono T, Takahashi N, Yamakuni K, Yang HE, Li Y, Ohue R, Nomura W, Sugawara T, Yu R, Kitamura N, Park SB, Kishino S, Ogawa J, Kawada T.
• 10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARgamma and stimulates adipogenesis.
  Biochem Biophys Res Commun. (2015) 459: 597-603.
Kim YI, Mohri S, Hirai S, Lin S, Goto T, Ohyane C, Sakamoto T, Takahashi H, Shibata D, Takahashi N, Kawada T.
• Tomato extract suppresses the production of proinflammatory mediators induced by interaction between adipocytes and macrophages
  Biosci Biotechnol Biochem (2015) 79:82-87.
Tu T H, Kim C-S, Nam-Goong I S, Nam C K, Kim YI, Goto T, Kawada T, Park T, Yoon P, Jung H, Ryoo Z Y, Park J W, Choi H-S, Yu R.
• 4-1BBL signaling promotes cell proliferation through reprogramming of glucose metabolism in monocytes/macrophages
  FEBS J　(2015) 282:1468-1480.
Takahashi H, Hara H, Goto T, Kamakari K, Wataru N, Mohri S, Takahashi N, Suzuki H, Shibata D, Kawada T.
• 3-Oxo-9(Z),11(E),15(Z)-octadecatrienoic Acid Activates Peroxisome Proliferator-　Activated Receptor γ in Adipocytes.
  Lipids (2015) 50:3-12.
Takahashi H, Goto T, Yamazaki Y, Kamakari K, Hirata M, Suzuki H, Shibata D, Takahashi N, Kawada T.
• Metabolomics reveal 1-palmitoyl lysophosphatidylcholine production by peroxisome proliferator-activated receptorα
  J Lipid Res. (2015)56:254-265.
Fukuda K, Matsumura T, Senokuchi T, Ishii N, Kinoshita H, Yamada S, Murakami S, Nakao S, Motoshima H, Kondo T, Kukidome D, Kawasaki S, Kawada T, Nishikawa T, Araki E.
• Statins meditate anti-atherosclerotic action in smooth muscle cells by peroxisome proliferator-activated receptor-γ activation.
  Biochem Biophys Res Commun. (2015);457:23-30.
河田照雄、高橋信之、後藤剛
• 『食品因子による栄養機能制御』第3章「脂肪・エネルギー代謝とβ-クリプトキサンチン」
  建帛社　東京 (2015)
後藤剛、河田照雄
• 肥満症の食事療法各論：「抗肥満機能性食品の現状と展望」
  『臨床栄養』第127巻4号 (2015年秋増刊号)

2014年研究業績

Le N H, Kim C-S, Park T, Park J H, Sung M-K, Lee D G, Hong S-M, Goto T, Kawada T, Yu R.
• Quercetin Protects Against Obesity-Induced Skeletal Muscle Inflammation and Atrophy.
  Mediators of Inflammation. (2014);2014:834294.
Yoshino S, Kim M, Awa R, Kuwahara H, Kano Y, Kawada T.
• Kaempferia parviflora extract increases energy consumption through activation of BAT in mice.
  Food Science & Nutrition (2014)2:634-7.
Yamamoto T, Takahashi H, Suzuki K, Hirano A, Kamei M, Goto T, Takahashi N, Kawada T.
• Theobromine Enhances Absorption of Cacao Polyphenol in Rats.
  Biosci Biotechnol Biochem. (2014)78:2059-2063.
Hien Tu T-H, Kim C-S, Kang J-H, Nam-Goong I, Nam G, Kim E-S, Kim Y-I, Choi J-I, Kawada T, Goto T, Park T, Choi MS, Yu R.
• Levels of 4-1BB transcripts and soluble 4-1BB protein are elevated in the adipose tissue of human obese subjects and are associated with inflammatory and metabolic parameters.
  Int J Obesity (2014) 38: 1075-1082.
Takahashi H, Kamakari K, Suzuki H, Mohri S, Goto T, Takahashi N, Matsumura Y, Shibata D, Kawada T.
• Localization of 9- and 13-oxo-octadecadienoic acids in tomato fruit.
  Biosci. Biotechnol. Biochem. (2014)78:1761-1764.
Moriwaki S, Murakami H, Takahashi N, UemuraT, Taketani K, HoshinoS, Tsuge N, Goto T, Kawada T.
• Yamogenin in fenugreek inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytes.
  Biosci. Biotechnol. Biochem. (2014)78:1231-1236.
Nagai H, Kawada T, Goto T, Kusudoh T, Tanaka T, Takahashi N.
• Phenolic compounds from leaves of Casimiroa edulis showed adipogenesis activity.
  Biosci. Biotechnol. Biochem. (2014)78:296-300.
Hirai S, Ohyane C, Kim Y-I, Lin S, Goto T, Takahashi N, Kim C-S, Kang J, Yu R, Kawada T.
• Involvement of mast cells in adipose tissue fibrosis.
  Am J Physiol. Endocrinology and Metabolism (2014) 306:E247-255.
Sakamoto T, Takahashi N, Goto T, Kawada T.
• Dietary factors evoke thermogenesis in adipose tissues.
  Obesity Research & Clinical Practice (2014)8:e533-539.
河田照雄
• 肥満と脂肪・エネルギー代謝に関する食品機能学的研究 (平成25年度日本栄養・食糧学会賞受賞)
  日本栄養・食糧学会誌　総説 (2014) 67巻3号
毛利晋輔、河田照雄
• 脂肪酸の魅力、再発見
  Functional Food　(2014)8:114 -116
毛利晋輔、河田照雄
• トマト由来オキソ脂肪酸：oxo-octadecadienoic acid (oxo-ODA)
  医学のあゆみ　印刷中

2013年研究業績

Kimura R, Takahashi N, Lin S, Goto T, Murota K, Nakata R, Inoue H, Kawada T.
• DHA attenuates postprandial hyperlipidemia via activating PPARalpha in intestinal epithelial cells.
  J Lipid Res. (2013)54:3258-3268.
Kimura R, Takahashi N, Goto T, Murota K, Kawada T.
• Activation of peroxisome proliferator-activated receptor-α (PPARα) in proximal intestine improves postprandial lipidemia in obese diabetic KK-Ay mice.
  Obes Res Clin Pract. (2013)7:e353-360.
Le N. H, Kim C-S, Tu T. H, Choi H. S, Kim B-S, Kawada T, Goto T, Park T, Park J.H.Y, Yu R.
• Blockade of 4-1BB and 4-1BBL Interaction Reduces Obesity-Induced Skeletal Muscle Inflammation.
  Mediators of Inflammation (2013);2013:865159.
Matsuura N, Gamo K, Miyachi H, Iinuma M, Kawada T, Takahashi N, Akao Y, Tosa H.
• γ-Mangostin from Garcinia mangostana pericarps as a dual agonist that activates Both PPARα and PPARδ.
  Biosci Biotechnol Biochem. (2013) 77:2430-2435.
Takahashi H, Suzuki H, Suda K, Yamazaki Y, Takino A, Kim Y-I, Goto T, Iijima Y, Aoki K, Shibata D, Takahashi N, Kawada T.
• Long-chain free fatty acid profiling analysis by liquid chromatography - mass spectrometry in mouse treated with peroxisome proliferator-activated receptor α.
  Biosci. Biotechnol. Biochem. (2013) 77(11):2288-93.
Kasahara Y, Sato K, Takayanagi Y, Mizukami H, Ozawa K, Hidema S, So K-H, Kawada T, Inoue N, Ikeda I, Roh S-G, Itoi K, Nishimori K.
• Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice.
  Endocrinology (2013) 154:4305-4315.
Yoshida H, Kanamori Y, Asano H, Hashimoto O, Murakami M, Kawada T, Matsui T, Funaba M.
• Regulation of brown adipogenesis by the Tgf-β family: Involvement of Srebp1c in Tgf-β- and Activin-induced inhibition of adipogenesis.
  Biochim Biophys Acta. (2013)10;1830(11):5027-5035.
Lin S, Hirai S, Yamaguchi Y, Goto T, Takahashi N, Tani F, Mutoh C, Sakurai T, Murakami S, Yu R, Kawada T.
• Taurine improves obesity-induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages.
  Mol Nutr Food Res. (2013) 57:2155-2165.
Takahashi N, Yao L, Kim M, Sasako H, Aoyagi M, Shono J, Tsuge N, Goto T, Kawada T.
• Dill seed extract improves abnormalities in lipid metabolism through peroxisome proliferator-activated receptor-α (PPAR-α) activation in diabetic obese mice.
  Mol Nutr Food Res. (2013) 57:1295-1299.
Sakamoto T, Takahashi N, Sawaragi Y, Naknukool S, Yu R, Goto T, Kawada T.
• Inflammation induced by RAW macrophages suppresses the UCP1 mRNA induction via ERK activation in 10T1/2 adipocytes.
  Am J Physiol Cell Physiol. (2013) 304:C729-738.
Lin S, Hirai S, Goto T, Sakamoto T, Takahashi N, Yano M, Sasaki T, Yu R, Kawada T.
• Auraptene suppresses inflammatory responses in activated RAW264 macrophages by inhibiting p38 MAPK activation
  Mol Nutr Food Res. (2013) 57:1135-1144.
Goto T, Kim YI, Takahashi N, Kawada T.
• Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors.　Review
  Mol Nutr Food Res. (2013) 57(1):20-33.
Goto T, Mori A, Nagaoka S.
• Soluble soy protein peptic hydrolysate stimulates adipocyte differentiation in 3T3-L1 cells.
  Mol Nutr Food Res. (2013) 57:1435-1445.
Kawai R, Ito S, Aida T, Hattori H, Kimura T, Furukawa T, Mori K, Sanbuissho A, Kawada T.
• Evaluation of primary and secondary responses to a T-cell-dependent antigen, keyhole limpet hemocyanin, in rats.
  J Immunotoxicol. (2013) 10: 40-48.
Oi-Kano Y, Kawada T, Watanabe T, Koyama F, Watanabe K, Senbongi R, Iwai K.
• Oleuropein supplementation increases urinary noradrenaline and testicular testosterone levels and decreases plasma corticosterone level in rats fed high-protein diet.
  J Nutr Biochem. (2013) 24: 887-893.
坂本智弥、高橋信之、後藤剛、河田照雄
• 褐色脂肪組織の生理的役割と機能制御
  細胞工学（2013）Vol.32. No.7, 2-7.
金英一、河田照雄
• トマトから見出された脂質代謝改善成分oxo-ODA
  医学のあゆみ(2013) 244:1063-1064.
高橋信之、後藤剛、河田照雄
• リコペンの効果
  内分泌・糖尿病・代謝内科(2013) 36(4):317-322
河田照雄　編著
• 脂肪の功罪と健康　書籍　2013年　建帛社発行

2012年研究業績

Goto T, Takahashi N, Kato S, Kim YI, Kusudo T, Taimatsu A, Egawa K, Kang MS, Hiramatsu T, Sakamoto T, Uemura T, Hirai S, Kobayashi M, Horio F, Kawada T.
• Bixin Activates PPARα and Improves Obesity-Induced Abnormalities of Carbohydrate and Lipid Metabolism in Mice.
  J Agric Food Chem. (2012) 60(48):11952-8. doi: 10.1021/jf303639f.
Le NH, Shin S, Tu TH, Kim CS, Kang JH, Goto T, Kawada T, Han SN, Yu R.
• Diet enriched with korean pine nut oil improves mitochondrial oxidative metabolism in skeletal muscle and brown adipose tissue in diet-induced obesity.
  J Agric Food Chem. (2012) 60(48):11935-41. doi: 10.1021/jf303548k.
Tu TH, Kim CS, Goto T, Kawada T, Kim BS, Yu R.
• 4-1BB/4-1BBL Interaction Promotes Obesity-Induced Adipose Inflammation by Triggering Bidirectional Inflammatory Signaling in Adipocytes/Macrophages.
  Mediators Inflamm. (2012);2012:972629. doi: 10.1155/2012/972629.
Sugiura C, Nishimatsu S, Moriyama T, Ozasa S, Kawada T, Sayama K.
• Catechins and Caffeine Inhibit Fat Accumulation in Mice through the Improvement of Hepatic Lipid Metabolism.
  J Obes. (2012) 2012:520510.
Kuroda M, Mimaki Y, Ohtomo T, Yamada J, Nishiyama T, Mae T, Kishida H, Kawada T.
• Hypoglycemic effects of clove (Syzygium aromaticum flower buds) on genetically diabetic KK-A(y) mice and identification of the active ingredients.
  J Nat Med. (2012) 66(2):394-399. doi: 10.1007/S11418-011-0593-Z
Goto T, Teraminami A, Lee JY, Ohyama K, Funakoshi K, Kim YI, Hirai S, Uemura T, Yu R, Takahashi N, Kawada T.
• Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice.
  J. Nutr. Biochem. (2012) 23(7):768-776. doi: 10.1016/j.jnutbio.2011.04.001
Yamada Y, Muraki A, Oie M, Kanegawa N, Oda A, Sawashi Y, Kaneko K, Yoshikawa M, Goto T, Takahashi N, Kawada T, Ohinata K.
• Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice.
  Am. J. Physiol. - Endocrinology and Metabolism (2012) 302: E433-40.
Kim YI, Hirai S , Goto T , Ohyane C , Takahashi H , Tsugane T, Konishi C, Fujii T, Inai S, Iijima Y, Aoki K, Shibata D, Takahashi N, Kawada T.
• Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice.
  PLoS ONE 7: e31317. doi:10.1371/journal.pone.0031317
Lee J-Y＊, Takahashi N＊, Yasubuchi M, Kim Y-I, Hashizaki H, Kim M-J, Sakamoto T,Goto T, Kawada T.
• Triiodothyronine Induces UCP1 Expression and Mitochondrial Biogenesis in Human Adipocytes.
  Am. J. Physiol. - Cell Physiology (2012) 302:C463-72. (* equal contributions)
金英一、後藤剛、木村梨乃、高橋信之、河田照雄
• 食品と肥満；核内受容体リガンドによる代謝制御
  カレントテラピー (2012) 30, 531-535.
河田照雄、坂本智弥
• 褐色脂肪：脂肪燃焼と食品機能
  週刊医学のあゆみ (2012)　242巻12号　942-946.

2011年研究業績

Goto T, Takahashi N, Funakoshi K, Kim Y-I, Teraminami A, Uemura T, Hirai S, Lee J-Y, Makishima M, Nakata R, Inoue H, Senju H, Matsunaga M, Horio F, Kawada T.
• Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways.
  Am. J. Physiol. - Endocrinology and Metabolism (2011) 301: E1022-32.
Takahashi N, Senda M, Lin S, Goto T, Yano M, Sasaki T, Murakami S, Kawada T.
• Auraptene regulates gene expression involved in lipid metabolism through PPAR-alpha activation in diabetic obese mice.
  Mol Nutr & Food Res. (2011) 58:1791-1797.
Goto T, Nagai H, Egawa K, Kim Y-I, Kato S, Taimatsu A, Sakamoto T, Hirai S, Ebisu S, Hohsaka T, Miyagawa H, Murakami S, Takahashi N, Kawada T.
• Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARgamma agonist.
  Biochem J. (2011) 438: 111-119.
Matsumura T, Kinoshita H, Ishii N, Fukuda K, Motoshima H, Senokuchi T, Taketa K, Kawasaki S, Nishimaki-Mogami T, Kawada T, Nishikawa T, Araki E.
• Telmisartan Exerts Antiatherosclerotic Effects by Activating Peroxisome Proliferator-Activated Receptor-gamma in Macrophages.
  Arterioscler Thromb Vasc Biol. (2011) 31: 1268-75.
Kim CS, Kim JG, Lee B-J, Choi M-S, Choi H-S, Kawada T, Lee K-U, Yu R.
• Deficiency for costimulatory receptor 4-1BB protects against obesity-induced inflammation and metabolic disorders.
  Diabetes (2011) 60:3159-68.
Ikeda R, Yanagisawa M, Takahasshi N, Kawada T, Kumazawa S, Yamaotsu N, Nakagome I, Hirono S and Tsuda T.
• Brazilian propolis-derived components inhibit TNF-alpha-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes.
  Biochim. Biophys. Acta. (2011) 1810: 695-703.
Takahashi H, Kim IL, Hirai S, Goto T, Ohyane C, Tsugane T, Konishi C, Fujii T, Inai S, Iijima Y, Aoki K, Shibata D, Takahashi N, Kawada T.
• Comparative and stability analyses of 9- and 13-oxo-octadecadienoic acid in various species of tomato.
  Biosci. Biotechnol. Biochem. (2011) 75: 1621-4.
Kim HJ, Kim HM, Kim CS, Jeong CS, Choi HS, Kawada T, Kim BS, Yu R.
• HVEM-deficient mice fed a high-fat diet are protected from adipose tissue inflammation and glucose intolerance.
  FEBS Lett. (2011) 585:2285-2290.
Kang JH, Tsuyoshi G, Le Ngoc H, Kim HM, Tu TH, Noh HJ, Kim CS, Choe SY, Kawada T, Yoo H, Yu R
• Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice.
  J Med Food. (2011) 14: 310-315.
Kimura R, Takahashi N, Murota K, Yamada Y, Kanzaki N, Murakami Y, Goto T, Kawada T.
• Activation of peroxisome proliferator-activated receptors induces intestinal fatty acid-oxidation to suppress lipid absorption.
  Biochem. Biophys. Res. Commun. (2011) 410: 1-6.
Nagai H, Goto T, Takahashi N, Deyashiki Y, Esaka Y, Kawada T.
• A method for simultaneous determination of 3T3-L1 adipocyte metabolites by liquid chromatography/mass spectrometry using a 13[C]-stable isotopes.
  Biosci. Biotechnol. Biochem. (2011) 75: 1485-9.
Sakamoto T*, Yamaguchi Y*, Goto T, Takahashi N, Kawada T.
• An in vitro analysis system using a fluorescence protein reporter for evaluating anti-inflammatory effects in macrophages.
  Biosci. Biotechnol. Biochem. (2011) 75: 1582-7. (* equal contributions)
Takahashi N*, Yao R*, Kang MS*, Senda M, Nishimura K, Hirai S, Yu R, Goto T, Ezaki Y, Kawada T.
• Dehydroabietic acid activates peroxisome proliferator-activated receptor-gamma (PPARgamma) to regulate gene expression involved in adipogenesis of 3T3-L1 adipocytes.
  BioFactors (2011) 37: 309-14. (* equal contributions)
Lee JY, Hashizaki H, Goto T, Sakamoto T, Takahashi N, Kawada T.
• Activation of PPAR-alpha enhances fatty acid oxidation in human adipocytes.
  Biochem. Biophys. Res. Commun. (2011) 407: 818-822.
Goto T, Lee J-Y, Teraminami A, Kim Y-I, Hirai S, Uemura T, Inoue H, Takahashi N, Kawada T.
• Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes.
  J Lipid Res. (2011) 52: 873-884.
Nagai H, Ebisu S, Abe R, Goto T, Takahashi N, Hohsaka T, Kawada T.
• Development of a novel PPARgamma ligand screening system using pinpoint fluorescence-probed protein.
  Biosci. Biotechnol. Biochem. (2011) 75: 337-341.
Uemura T, Goto T, Kang M-S, Mizoguchi N, Hirai S, Lee, J-Y, Nakano Y, Shono J, Hoshino S, Taketani K, Tsuge N, Narukami T, Makishima M, Takahashi N, Kawada T.
• Diosgenin, the Main Aglycon of Fenugreek, Inhibits LXRα Activity in HepG2 cells and Decreases Plasma and Hepatic Triglycerides in Obese, Diabetic Mice.
  J. Nutr. (2011) 141: 17-23.
Kim Y-I, Hirai S, Takahashi H, Goto T, Ohyane C, Tsugane T, Konishi C, Fujii T, Inai S, Iijima Y, Aoki K, Shibata D, Takahashi N, Kawada T.
• 9-oxo-10(E),12(E)-octadecadienoic acid derived from tomato is a potent peroxisome proliferator-activated receptor α agonist to decrease triglyceride accumulation in mouse primary hepatocytes.
  Mol. Nutr. Food Res. (2011) 55: 585-593.
河田照雄
• カプサイシンの機能性を学ぼう　
  月刊「食生活」2011年7月号
河田照雄
• 巻頭言：脂肪細胞 ふるきを尋ね、あたらしきを観る
  肥満研究 201１年1号
後藤剛、李周容、高橋信之、河田照雄
• メタボリックシンドロームー基礎・臨床の最新知見-　第２版　メタボリックシンドローム発症基盤としての脂肪細胞機能異常：脂肪細胞のライフサイクルとその制御因子
  日本臨牀 （印刷中）
河田照雄、大山夏奈、高橋信之
• β-クリプトキサンチンー糖・脂質代謝改善作用
  Functional Food (2011) 4: 294-299
河田照雄、高橋信之、後藤剛
• 褐色脂肪研究の新展開：体熱産生・褐色脂肪機能と食品因子
  肥満研究　(2011) 17: 96-101
河田照雄
• 褐色脂肪・UCP1を活性化させる脂肪酸はありますか？
  肥満と糖尿病 (2011) 10: 印刷中

2010年研究業績

Kang J-H, Goto T, Han I-S, Kim C-S, Kawada T, Kim Y-M, Yu R.
• Dietary Capsaicin reduces Obesity-induced Insulin Resistance and Hepatic Steatosis in Obese Mice fed a High-fat Diet.
  Obesity (2010) 18: 780-787.
Kim CS, Tu TH, Kawada T, Kim BS, Yu R.
• The Immune Signaling Molecule 4-1BB Stimulation Reduces Adiposity, Insulin Resistance, and Hepatosteatosis in Obese Mice.
  Endocrinology. (2010) 151: 4725-4735.
Ishii N, Matsumura T, Kinoshita H, Fukuda K, Motoshima H, Senokuchi T, Nakao S, Tsutsumi A, Kim-Mitsuyama S, Kawada T, Takeya M, Miyamura N, Nishikawa T, Araki E.
• Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice.
  Arterioscler Thromb Vasc Biol. (2010) 30: 1598-15605.
Uemura T, Hirai S, Mizoguchi N, Goto T, Lee JY, Taketani K, Nakano Y, Shono J, Hoshino S, Tsuge N, Narukami T, Takahashi N, Kawada T.
• Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues.
  Mol. Nutr. Food Res. (2010) 54: 1596-1608.
Inoue, H., Takahashi, N., Okada, Y. and Konishi, M.
• Volume-sensitive outwardly rectifying chloride channel in white adipocytes. Am.
  J. Physiol.: Cell Physiol. (2010) 298: C900-C909.
Goto T, Takahashi N, Hirai S, Kawada T.
• Various terpenoids derived from herbal and dietary plants function as PPAR modulators and regulate carbohydrate and lipid metabolism.
  PPAR Res. (2010) 2010: 483958.
Hirai S, Takahashi N, Goto T, Lin S, Uemura T, Yu R, Kawada T.
• Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies.
  Mediators Inflamm. (2010) 2010: 367838.
Fujitani Y, Aritake K, Kanaoka Y, Goto T, Takahashi N, Fujimori K, Kawada T.
• Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo.
  FEBS J. (2010) 277: 410-419.
Hirai, S.*, Uemura, T.*, Mizoguchi, N., Lee, J. Y., Taketani, K., Nakano,Y., Hoshino, S., Tsuge, N., Narukami, T., Yu, R., Takahashi, N. and Kawada,T.
• Diosgenin attenuates inflammatory changes in the interaction between adipocytes and macrophages.
  Mol. Nutr. Food Res. (2010) 54: 1-8. (* equal contributions)
後藤剛、李周容、寺南亜紀、高橋信之、河田照雄
• 肥満症（第２版）：栄養素によるエネルギー代謝調節　『脂肪細胞での代謝調節』
  日本臨牀　増刊号　(2010) 156-161.
河田照雄
• 巻頭言：脂肪細胞讃歌
  The Lipid 2010年1月号
高橋信之、河田照雄
• マッキー生化学（第4版）第16章「代謝の統合的理解」翻訳
  化学同人（2010）

2009年研究業績

Takahashi N*, Goto T*, Taimatsu A, Egawa K, Katoh S, Kusudo T, Sakamoto T, Ohyane C, Lee J.Y., Kim Y.I., Uemura T, Hirai S, and Kawada, T.
• Bixin regulates gene expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPAR-gamma activation.
  Biochem. Biophys. Res. Commun. (2009) 390: 1372-1376. (* equal contributions)
Ando C*, Takahashi N*, Hirai S*, Lee J.Y., Goto T, Yu R, and Kawada T.
• Luteolin, a food-derived flavonoid, inhibits adipocyte-dependent activation of macrophages in adipose tissues.
  FEBS Lett. (2009) 583: 3649-3654. (* equal contributions)
Kang M.S., Hirai S, Goto T, Kuroyanagi K, Kim I.Y., Ohyama K, Uemura T, Lee J.Y., Sakamoto T, Ezaki Y, Yu R, Takahashi N, and Kawada T.
• Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation of mouse adipose tissues.
  BioFactors (2009) 35: 442-448.
Iwasaki K, Kamauchi S, Wadahama H, Ishimoto M, Kawada T, Urade R.
• Molecular cloning and characterization of soybean protein disulfide isomerase family proteins with nonclassic active center motifs.
  FEBS J. (2009) 276: 4130-4141.
Takahashi N, Goto T, Hirai S, Uemura T, and Kawada T.
• Genome science of lipid metabolism and obesity.
  in: FOOD FACTORS for HEALTH PROMOTION (Dr. T. Yoshikawa, Kyoto, Japan), Forum Nutri. (2009) 61: 25-38.
Goto T, Hirai S, Yu R, Takahashi N, and Kawada T.
• Obesity and Nuclear Receptors : Effective Genomic Strategies in Functional Foods.
  in: NUTRIGENOMICS AND PROTEOMICS IN HEALTH AND DISEASE (Yoshinori Mine, Kazuo Miyashita and Fereidoon Shahidi,Eds) (2009) 47-58. WILEY-BLACK WELL
Goto T, Hirai S, Yu R, Takahashi N, and Kawada T.
• Isoprenols : Effective Genomic Strategies in Functional Foods.
  in: NUTRIGENOMICS AND PROTEOMICS IN HEALTH AND DISEASE (Yoshinori Mine, Kazuo Miyashita and Fereidoon Shahidi,Eds) (2009) 301-310. WILEY-BLACK WELL
Lee HS, Park JH, Kang JH, Kawada T, Yu R, Han IS
• Chemokine and chemokine receptor gene expression in the mesenteric adipose tissue of KKAy mice.
  Cytokine. (2009) 46: 160-165.
Mochizuki Y, Maebuchi M, Kohno M, Hirotsuka M, Wadahama H, Moriyama T, Kawada T, Urade R.
• Changes in lipid metabolism by soy beta-conglycinin-derived peptides in HepG2 cells.
  J Agric Food Chem. (2009) 57: 1473-1480.
高橋信之、大山夏奈、千田真里、西村加奈子、河田照雄
• カロテノイドの科学と最新応用技術　第11章「カンキツ由来カロテノイドの機能性」
  シーエムシー出版（2009）

2008年研究業績

Taketa K, Matumura T, Yano M, Ishii N, Senokuchi T, Motoshima H, Murata Y, Kim-Mitsuyama S, Kawada T,Itabe H, Takeya M, Nishikawa T, Tsuruzoe K, Araki E.
• Ox-LDL activates PPARalpha and PPARgamma through MAPK-dependent COX-2 expression in macrophages.
  J Biol Chem. (2008) 283: 9852-9862.
Takahashi N, Kang M-S, Kuroyanagi K, Goto T, Hirai S, Ohyama K, Lee J-Y, Yu R, Yano M, Sasaki T, Murakami S, Kawada T.
• Auraptene, a citrus fruit compound, regulates gene expression as a PPAR-alpha agonist in HepG2 hepatocytes.
  BioFactors. (2008) 33: 25-32.
Oi-Kano Y, Kawada T, Watanabe T, Koyama F, Watanabe K, Senbongi R, Iwai K.
• Oleuropein, a phenolic compound in etra virgin olive oil, increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats. J Nutr Sci Vitaminol (Tokyo). (2008) 54: 363-307.
Isa Y, Miyakawa Y, Yanagisawa M, Goto T, Kang MS, Kawada T, Morimitsu Y, Kubota K, Tsuda T.
• 6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanism in 3T3-L1 adipocytes.
  Biochem Biophys Res Commun. (2008) 373: 429-434.
Takayanagi Y, Kasahara Y, Onaka T, Takahashi N, Kawada T, Nishimori K.
• Oxytocin receptor-deficient mice developed late onset obesity.
  Neuro Report. (2008) 19: 951-955.
Kang MS, Hirai S, Goto T, Kuroyanagi K, Lee JY, Uemura T, Ezaki Y, Takahashi N, Kawada T.
• Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in Macrophages and adipocytes to regulate inflammation.
  Biochem Biophys Res Commun. (2008) 369: 333-338.
Kawada T, Goto T, Hirai S, Kang M-S, Uemura T, Yu R, Takahashi N.
• Dietary regulation of nuclear receptors in obesity-related metabolic syndrome.
  Asia Pac J Clin Nutr. (2008) 17(Suppl): 126-130.
Kuroyanagi K, Kang MS, Goto T, Hirai S, Ohyama K, Kusudo T, Yu R, Yano M, Sasaki T, Takahashi N, Kawada T.
• Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocyte.
  Biochem Biophys Res Commun. (2008) 366: 219-225.
Kim C-S, Lee SC, Kim BS, Kim YM, Kawada T, Kwon B-S Yu R.
• Visceral fat accumlation causes the atrophy of mesenteric lymph nodes in obese mice fed a high-fat diet.
  Obesity. (2008) 16: 1261-1269.
Kang JH, Han IH, Sung MK, Yoo H, Kim YG, Kim JS, Kawada T, Yu R.
• Soybean saponin inhibits tumor cell metastasis by modulating expression of MMP-2, MMP-9 and TIMP-2.
  Cancer Lett. (2008) 261: 84-92.
Wadahama H, Kamauchi S, Nakamoto Y, Nishizawa K, Ishimoto M, Kawada T, Urade R.
• A novel plant protein disulfide isomerase family homologous to animal P5: molecular cloning and characterization as a functional protein for folding of soybean seed storage protein.
  FEBS J. (2008) 275: 399-410.
河田 照雄、後藤 剛、平井 静、高橋 信之
• 脂質代謝と生活習慣病・メタボリックシンドローム
  生物工学　(2008)　86: 469-487.
平井 静、後藤 剛、柳 梨娜、高橋 信之、河田 照雄
• 肥満と脂肪エネルギー代謝：肥満・メタボリックシンドロームと食品機能
  建帛社　(2008)
河田 照雄
• 栄養学研究の最前線：病態栄養分野の進歩と課題
  建帛社　(2008)
河田 照雄
• 食品機能性の科学：辛味成分およびフィトケミカル
  産業技術サービスセンター　(2008)
河田　照雄
• 肥満・メタボッリックシンドロームと食品
  ネスレ栄養科学レビュー（http://www.nestle.co.jp/science/review/review0712.htm）

2007年研究業績

Kasahara Y, Takayanagi Y, Kawada T, Itoi K, Nishimori K.
Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure.
Biosci Biotechnol Biochem. (2007) 71: 3122-3126. Sakane N, Kotani K, Hioki C, Yoshida T, Kawada T.
• Up-regulation of muscle uncoupling protein 3 gene expression by calcium channel blocker, Benidipine Hydrochloride in rats.
  Endocr. J. (2007) 54: 771-775.
Hirai S, Kim Y-I, Goto T, Kang M-S, Yoshimura M, Obata A, Yu R, Kawada T.
• Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages.
  Life Sci. (2007) 81: 1272-1279.
Kang J-H, Kim C-S,Han I-S, Kawada T, Yu R.
• Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages.
  FEBS Letters (2007) 581: 4389-439
Yano Y, Matsumura T, Senokuchi T, Ishii N, Motoshima H, Taguchi T, Matsuo T, Sonoda K, Kukidome D, Sakai M, Kawada T, Nishikawa T, Araki E.
• Troglitazone inhibits oxidized low-density lipoprotein-induced macrophage proliferation: Impact of the suppression of nuclear translocation of ERK1/2.
  Atherosclerosis (2007) 191: 22-32.
Yano Y, Matsumura T, Senokuchi T, Ishii N, Murata Y, Taketa K, Motoshima H, Taguchi T, Sonoda K, Kukidome D, Takuwa Y, Kawada K, Brownlee M, Nishikawa T, Araki E.
• Statins Activate Peroxisome Proliferator-Activated Receptor γ Through Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase-Dependet Cyclooxygenase-2 Expression in Macrophages.
  Circ. Res. (2007) 100: 1442-1451.
Oi-Kano Y, Kawada T, Watanabe T, Koyama F, Watanabe K, Senbongi R, Iwai K.
• Extra virgin olive oil increases uncoupling protein 1 content in brown adipose tissue, and enhances noradrenaline and adrenaline secretion in rats.
  J Nutr Biochem. (2007) 18: 685-692.
Woo H-M , Kang J-H , Kim C-S, Kawada T, Yoo H, Sung M-K, Yu R.
• Spices-derived active components inhibit obesity-induced inflammatory responses by modulating the behavior of adipose tissue macrophages and the release of MCP-1 from adipocytes.
  Life Sci. (2007) 80: 926-931.
Kawachi H, Moriya NH, Korai T, Tanaka S, Watanabe M, Matsui T, Kawada T, Yano H.
• Nitric oxide suppresses preadipocyte differentiation in 3T3-L1 culture.
  Mol. Cell. Biochem. (2007) 300: 61-67.
Kondoh Y, Teruo Kawada, Reiko Urade.
• Activation of caspase 3 in HepG2 cells by elaidic acid (t18:1) Biochim.
  Biophys Acta (2007) 1771: 500-505.
Urade R
• Cellular response to unfolded proteins in the endoplasmic reticulum of plants.
  FEBS Journal (2007) 102: 225-231.
Wadahama H, Kamauchi S, Ishimoto M, Kawada T and Urade R
• Protein disulfide isomerase family proteins involved in soybean protein biogenesis.
  FEBS Journal (2007) 274: 687-703.
Ukai T and Urade R
• Cooperation of phosphatidylcholine with endogenous lipids of wheat flour for an increase in dough　volume.
  Food Chemistry (2007) 102: 225-231
植村 卓、後藤 剛、河田 照雄
• 抗肥満食品・素材の開発と応用展開；抗肥満のメカニズム
  シーエムシー出版　(2007)
後藤 剛、植村 卓、村上 陽子、河田 照雄
• メタボリック症候群と栄養：メタボリック症候群と食品機能ー糖尿病関連
  幸書房 (2007) 175-187.
平井 静、楠堂 達也、向井 佐輝子、河田 照雄
• 培養脂肪細胞の分化プロトコール、「糖尿病カレントライブラリー」
  文光堂 (2007) 276-279.
Meet the Professor-13 Dr. Christian Dani
• ヒト脂肪組織由来多能性幹細胞(hMADS)の確立とその応用研究，および脂肪細胞分化と発達のキー分子，ＦＧＦ，ＥＲＫの機構探索
  Adiposcience (2007) 4: 88-95.